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Imaging evaluation in animal experiments. ( A ) Schematic diagram of animal experiments. ( B ) Pre- and postoperative <t>speckle</t> contrast imaging of the periosteum at the lateral femoral condyle. ( C ) X-ray and CT images of the bone defect repair site at 6 and 12 weeks postoperatively (green indicates the implanted scaffold; gray indicates the surrounding newly formed bone). ( D-G ) Quantitative analysis of BV/TV, Tb.N, Tb. Sp, Tb.Th. Data are presented as mean values ± s.d. (n = 3). ( H ) <t>Laser</t> speckle contrast images of the bone defect repair site in different groups at 6 and 12 weeks postoperatively. ( I-J ) Quantitative analysis of vessel intensity and <t>perfusion</t> integrated density. Data are presented as mean values ± s.d. (n = 3). ns, no significant (p > 0.05), ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 (one-way ANOVA).
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Imaging evaluation in animal experiments. ( A ) Schematic diagram of animal experiments. ( B ) Pre- and postoperative <t>speckle</t> contrast imaging of the periosteum at the lateral femoral condyle. ( C ) X-ray and CT images of the bone defect repair site at 6 and 12 weeks postoperatively (green indicates the implanted scaffold; gray indicates the surrounding newly formed bone). ( D-G ) Quantitative analysis of BV/TV, Tb.N, Tb. Sp, Tb.Th. Data are presented as mean values ± s.d. (n = 3). ( H ) <t>Laser</t> speckle contrast images of the bone defect repair site in different groups at 6 and 12 weeks postoperatively. ( I-J ) Quantitative analysis of vessel intensity and <t>perfusion</t> integrated density. Data are presented as mean values ± s.d. (n = 3). ns, no significant (p > 0.05), ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 (one-way ANOVA).
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Imaging evaluation in animal experiments. ( A ) Schematic diagram of animal experiments. ( B ) Pre- and postoperative <t>speckle</t> contrast imaging of the periosteum at the lateral femoral condyle. ( C ) X-ray and CT images of the bone defect repair site at 6 and 12 weeks postoperatively (green indicates the implanted scaffold; gray indicates the surrounding newly formed bone). ( D-G ) Quantitative analysis of BV/TV, Tb.N, Tb. Sp, Tb.Th. Data are presented as mean values ± s.d. (n = 3). ( H ) <t>Laser</t> speckle contrast images of the bone defect repair site in different groups at 6 and 12 weeks postoperatively. ( I-J ) Quantitative analysis of vessel intensity and <t>perfusion</t> integrated density. Data are presented as mean values ± s.d. (n = 3). ns, no significant (p > 0.05), ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 (one-way ANOVA).
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Imaging evaluation in animal experiments. ( A ) Schematic diagram of animal experiments. ( B ) Pre- and postoperative <t>speckle</t> contrast imaging of the periosteum at the lateral femoral condyle. ( C ) X-ray and CT images of the bone defect repair site at 6 and 12 weeks postoperatively (green indicates the implanted scaffold; gray indicates the surrounding newly formed bone). ( D-G ) Quantitative analysis of BV/TV, Tb.N, Tb. Sp, Tb.Th. Data are presented as mean values ± s.d. (n = 3). ( H ) <t>Laser</t> speckle contrast images of the bone defect repair site in different groups at 6 and 12 weeks postoperatively. ( I-J ) Quantitative analysis of vessel intensity and <t>perfusion</t> integrated density. Data are presented as mean values ± s.d. (n = 3). ns, no significant (p > 0.05), ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 (one-way ANOVA).
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Imaging evaluation in animal experiments. ( A ) Schematic diagram of animal experiments. ( B ) Pre- and postoperative <t>speckle</t> contrast imaging of the periosteum at the lateral femoral condyle. ( C ) X-ray and CT images of the bone defect repair site at 6 and 12 weeks postoperatively (green indicates the implanted scaffold; gray indicates the surrounding newly formed bone). ( D-G ) Quantitative analysis of BV/TV, Tb.N, Tb. Sp, Tb.Th. Data are presented as mean values ± s.d. (n = 3). ( H ) <t>Laser</t> speckle contrast images of the bone defect repair site in different groups at 6 and 12 weeks postoperatively. ( I-J ) Quantitative analysis of vessel intensity and <t>perfusion</t> integrated density. Data are presented as mean values ± s.d. (n = 3). ns, no significant (p > 0.05), ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 (one-way ANOVA).
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Image Search Results


Imaging evaluation in animal experiments. ( A ) Schematic diagram of animal experiments. ( B ) Pre- and postoperative speckle contrast imaging of the periosteum at the lateral femoral condyle. ( C ) X-ray and CT images of the bone defect repair site at 6 and 12 weeks postoperatively (green indicates the implanted scaffold; gray indicates the surrounding newly formed bone). ( D-G ) Quantitative analysis of BV/TV, Tb.N, Tb. Sp, Tb.Th. Data are presented as mean values ± s.d. (n = 3). ( H ) Laser speckle contrast images of the bone defect repair site in different groups at 6 and 12 weeks postoperatively. ( I-J ) Quantitative analysis of vessel intensity and perfusion integrated density. Data are presented as mean values ± s.d. (n = 3). ns, no significant (p > 0.05), ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 (one-way ANOVA).

Journal: Bioactive Materials

Article Title: Reconstructing the ischemic osteogenic microenvironment through hierarchical scaffolds orchestrating Mg 2+ signaling and neuropilin-1–mediated angiogenesis

doi: 10.1016/j.bioactmat.2026.02.031

Figure Lengend Snippet: Imaging evaluation in animal experiments. ( A ) Schematic diagram of animal experiments. ( B ) Pre- and postoperative speckle contrast imaging of the periosteum at the lateral femoral condyle. ( C ) X-ray and CT images of the bone defect repair site at 6 and 12 weeks postoperatively (green indicates the implanted scaffold; gray indicates the surrounding newly formed bone). ( D-G ) Quantitative analysis of BV/TV, Tb.N, Tb. Sp, Tb.Th. Data are presented as mean values ± s.d. (n = 3). ( H ) Laser speckle contrast images of the bone defect repair site in different groups at 6 and 12 weeks postoperatively. ( I-J ) Quantitative analysis of vessel intensity and perfusion integrated density. Data are presented as mean values ± s.d. (n = 3). ns, no significant (p > 0.05), ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 (one-way ANOVA).

Article Snippet: Under isoflurane anesthesia, the lateral knee region was surgically exposed and imaged using a laser speckle perfusion system (PeriCam PSI System, Perimed AB, Sweden; 785 nm).

Techniques: Imaging